Raphinha struggled with various injuries to his right thigh last season.
Brazil coach Carlo Ancelotti could turn to either of the 19-year-old duo of Endrick and Rayan, or Arsenal's Gabriel Martinelli to replace Raphinha.
Five-time world champions Brazil, who have four points from two games, round off their Group C campaign against Scotland on Wednesday in Miami.
That game could provide Neymar, sidelined for a month with a calf injury, a first international appearance since October 2023.