Sixteen teams will discover their opponents in the Champions League knockout draw on Friday.
The eight winners of the two-legged knockout phase play-offs will join the top eight sides from the league phase in the round of 16 draw. The top eight from the league phase will be seeded for this stage.
Teams can be drawn against clubs they faced in the league phase or from the same national association.
Round of 16 contenders:
Top eight from the league phase (alphabetical order): Arsenal, Barcelona, Bayern München, Chelsea, Liverpool, Man City, Sporting CP, Tottenham.
Knockout phase play-off winners (alphabetical order): Atalanta, Atleti, Bodø/Glimt, Galatasaray, Leverkusen, Newcastle, Paris, Real Madrid.
Friday's draw will also allocate a side of the bracket for all teams, meaning they will know who they could potentially meet in the quarterfinals, semifinals, and final.
Last-16 first legs will take place on 10 or 11 March, with the return legs scheduled for 17–18 March.
The Puskás Aréna in Budapest, Hungary, will host the 2025–26 final on 30 May.
How does the last-16 draw work?
The eight winners of the play-offs will meet the top-eight finishers from the league phase.
From this point onward, the competition adopts a knockout format, with each fixture, except the final, contested over two legs.
As with the play-offs, teams' final ranking in the league phase will influence seeding in the last 16, with seeded sides—those that finished in the top eight of the league—given the advantage of playing the second leg at home.
This is the first season in which league phase positions will also influence seeding for the quarter-finals and semi-finals.
Teams finishing first to fourth in the league phase will be seeded for the quarter-finals and will have the home advantage in their second-leg tie.
The top two teams from the league will also be seeded for the semi-finals, earning the benefit of playing the second leg of their semi-final at home, should they reach that stage.
If a seeded team does not progress to the quarter-finals or semi-finals, the team that knocks them out will inherit their seeding position.
Who can meet eho in Friday's Round of 16 Draw?
Head-to-Head Records (UEFA competitions only)
Top Eight from the League Phase
Arsenal
Can play: Atalanta, Leverkusen
Previous meetings:
Atalanta P1 W0 D1 L0 F0 A0
Leverkusen P2 W1 D1 L0 F5 A2
Barcelona
Can play: Newcastle, Paris
Previous meetings:
Newcastle P5 W4 D0 L1 F10 A5
Paris P16 W6 D4 L6 F29 A29
Bayern München
Can play: Atalanta, Leverkusen
Previous meetings:
Atalanta N/A
Leverkusen P2 W2 D0 L0 F5 A0
Chelsea
Can play: Newcastle, Paris
Previous meetings:
Newcastle N/A
Paris P8 W2 D3 L3 F11 A10
Liverpool
Can play: Atleti, Galatasaray
Previous meetings:
Atleti P9 W4 D2 L3 F14 A12
Galatasaray P5 W1 D2 L2 F6 A7
Man City
Can play: Bodø/Glimt, Real Madrid
Previous meetings:
Bodø/Glimt P1 W0 D0 L1 F1 A3
Real Madrid P15 W5 D5 L5 F26 A25
Sporting CP
Can play: Bodø/Glimt, Real Madrid
Previous meetings:
Bodø/Glimt N/A
Real Madrid P6 W1 D1 L4 F6 A12
Tottenham
Can play: Atleti, Galatasaray
Previous meetings:
Atleti P1 W1 D0 L0 F5 A1
Galatasaray P1 W0 D0 L1 F2 A3
Knockout Phase Play-off Winners
Atalanta
Can play: Arsenal, Bayern
Previous meetings:
Arsenal P1 W0 D1 L0 F0 A0
Bayern N/A
Atleti
Can play: Liverpool, Tottenham
Previous meetings:
Liverpool P9 W3 D2 L4 F12 A14
Tottenham P1 W0 D0 L1 F1 A5
Bodø/Glimt
Can play: Man City, Sporting CP
Previous meetings:
Man City P1 W1 D0 L0 F3 A1
Sporting CP N/A
Galatasaray
Can play: Liverpool, Tottenham
Previous meetings:
Liverpool P5 W2 D2 L1 F7 A6
Tottenham P1 W1 D0 L0 F3 A2
Leverkusen
Can play: Arsenal, Bayern
Previous meetings:
Arsenal P2 W0 D1 L1 F2 A5
Bayern P2 W0 D0 L2 F0 A5
Newcastle
Can play: Barcelona, Chelsea
Previous meetings:
Barcelona P5 W1 D0 L4 F5 A10
Chelsea N/A
Paris
Can play: Barcelona, Chelsea
Previous meetings:
Barcelona P16 W6 D4 L6 F29 A29
Chelsea P8 W3 D3 L2 F10 A11
Real Madrid
Can play: Man City, Sporting CP
Previous meetings:
Man City P15 W5 D5 L5 F25 A26
Sporting CP P6 W4 D1 L1 F12 A6
